Preimplantation Genetic Testing
Before embryo implantation, screening for chromosome (copy-number) abnormalities, single-gene inherited disorders, or chromosomal structural abnormalities to select embryos suitable for transfer.
Before embryo implantation, screening for chromosome (copy-number) abnormalities, single-gene inherited disorders, or chromosomal structural abnormalities to select embryos suitable for transfer.
The physician chooses the testing type based on age, history, family genetic disease, and treatment goals to support pregnancy chances and reduce miscarriage risk.
Screens embryo chromosome number abnormalities. PGT-A mainly detects abnormal chromosome numbers and cannot detect single-gene diseases, chromosomal recombination, inversions, balanced translocations, uniparental disomy (UPD), and other abnormalities. After pregnancy through PGT-A, chorionic villus sampling or amniocentesis is still recommended.
Tests for known single-gene diseases. It aims to select embryos that do not carry the known genetic condition for transfer, but cannot detect untested mutations, non-familial genetic disease, small chromosomal deletions, or chromosome number abnormalities. After pregnancy through PGT-M, chorionic villus sampling or amniocentesis is still recommended.
Applies to structural abnormalities such as balanced translocations. PGT-SR can be combined with PGT-A to confirm whether embryo chromosome copy number is correct.
After egg retrieval, the eggs and sperm are fertilized in the laboratory, and embryos are cultured to the day 5-6 blastocyst stage.
Embryo biopsy is performed in the laboratory, and the biopsied embryos are cryopreserved at the same time.
Testing takes about 14 working days.
After the PGS/PGT-A report is complete, a normal embryo is selected for transfer in the next menstrual cycle.
| Type | Purpose | Suitable for objects |
|---|---|---|
| PGT-A / PGS | Chromosome number screening | Advanced age, repeated failure, family history of chromosomal abnormality |
| PGT-M / PGD | Single-gene disease testing | Couples with a known or suspected family history of monogenic disease |
| PGT-SR | Chromosomal structural abnormality testing | Balanced translocation or structural rearrangement carriers |
Studies show that embryo chromosomal abnormality rates rise with age. Selecting chromosomally normal embryos through PGT-A can improve implantation, reduce miscarriage risk, and increase live birth rates.
Biopsy performed by an experienced embryologist carries a low risk, but each case still requires individual assessment.
Not always. It is assessed based on age, history, family genetic risk, and treatment goals.
More certainty.
BRC helps you determine the PGT testing type that fits your situation.